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The polyunsaturated nature of PUFAs enables critical signaling and membrane fluidity functions while conferring peroxidation susceptibility, rendering membranes rich in PUFA-phospholipids-synthesized by ACSL4 and LPCAT3-vulnerable to ferroptosis through iron-catalyzed Fenton reaction-mediated oxidation (116)

JAMA Intern Med 177:633640 Lincoff AM, Wolski K, Nicholls SJ, Nissen SE (2007) Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus a meta-analysis of randomized trials

Physicians usually give glutathione shots to patients who believe they are stalled on their weight loss

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It serves as a cofactor for the methionine synthase enzyme, which transfers methyl groups to enable the regeneration of methionine from homocysteine