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It participates in the modulation of the activity and localization of numerous enzymes and receptors [147, 160, 161], takes part in the regulation of many physiological processes in the brain [147, 162], including synaptic plasticity [163, 164], axonal elongation, and neuronal survival [147, 165]
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In people without pernicious anemia, about 0.5 g/day of B12 is reabsorbed by enterohepatic circulation in which B12-containing bile is secreted by the liver into the digestive tract where the B12 is then reabsorbed via intrinsic factor
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Human TH17 lymphocytes induce blood-brain barrier disruption and central nervous system inflammation
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