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TDP-43-induced inflammatory responses in microglia were attenuated when treated with an IL-6 trans-signaling inhibitor in vitro , suggesting that IL-6 trans-signaling may act as a potential driver of inflammation in ALS pathogenesis (Risby-Jones et al., 2025)

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BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models