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Results from the long-term follow-up of Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, the Action in Diabetes and Vascular disease study, the PreterAx and DiamicroN-MR Controlled Evaluation (ADVANCE) study, and the Veterans Affairs Diabetes Trial (VADT) also suggested improvements in microvascular outcomes with early intensive glycemia control

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Adequate antioxidant defenses, including optimal glutathione status, are essential for protecting brain cells from this oxidative burden