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doi: 10.7759/cureus.86363
The two peptides activate different receptors on pituitary somatotroph cells: the CJC-1295 acts via the GHRH-R and theIpamorelin via GHS-R1a
Since clinical trials and research for retatrutide are still in progress, there is no official or finalized dosing schedule yet
The FDA has also approved Wegovy for adolescents aged 12 years and older who have obesity, defined as: a BMI at or above the 95th percentile for age and sex, based on CDC growth charts Must weigh at least 60 kg (132 lbs) Administered as a once-weekly subcutaneous injection Must be used in conjunction with a reduced-calorie diet and increased physical activity If an adolescent does not achieve at least a 5% reduction in BMI after 12 weeks on the 2.4 mg or maximum tolerated dose, treatment should be discontinued and re-evaluated In March 2024, the FDA approved Wegovy to reduce the risk of cardiovascular death, stroke, and heart attack in adults with cardiovascular disease and either obesity or overweight
Form: vial with 2 mg lyophilized powder + 1 ml ampoule of injection water for reconstitution
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