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General switching guidelines: Notice that even people on the maximum semaglutide dose (2.4 mg) typically start tirzepatide at 5 mg, not at a higher dose

When the exogenous agonist is removed, your ghrelin-producing cells in the stomach fundus rapidly increase output to restore signaling, but the receptors haven't yet downregulated back to normal density

It also contains prebiotic fiber, says Katherine Brooking, RD, in practice in North Salem, New York, and coauthor of The Real Skinny

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