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In particular, the Nlrp3 inflammasome is a cytosolic multiprotein complex expressed in immune/inflammatory cells as well as cardiovascular system cells, including endothelial cells, myofibroblasts/fibroblasts, and cardiomyocytes, which, through the processing and release of interleukin (IL)-1 and IL-18 and the induction of cell death processes (pyroptosis, apoptosis, and necroptosis), plays a key role in the maintenance of host homeostasis and in sustaining the pathophysiological events underlying CVDs (48)

Products outside the formal drug pipeline may enter the market with limited evidence and oversight, especially when labeled as dietary supplements rather than drugs or injectables

Pediatr Infect Dis J

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The use of antioxidants such as glutathione (GSH) during chemotherapy or radiation therapy is controversial and probably not recommended [6]