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[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD

FIGURE 4 Berberine activated GLP-1/GLP-1R/PKA signaling pathway in Min6 cell Min6 cell is a cell line established in insulinoma obtained by targeted expression in transgenic mice, and retains the physiological characteristics of normal cell

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Interestingly however, a more modest effect was seen on GLP-1R endocytosis when -arrestins were ablated, suggesting that the role of desensitization by -arrestins supersedes their role in GLP-1R trafficking