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235 An uncontrolled study in 918 children with restlessness and difficulty sleeping found tablets with 160 mg valerian and 80 mg lemon balm, taken at doses of up to two tablets twice daily for at least four weeks, improved symptoms in 81% of participants

Clinical outcomes The primary end points were the participant incidence of TEAEs, changes in laboratory safety tests, vital signs and 12-lead electrocardiograms

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It is the number one reason people discontinue treatment, reduce their doses below therapeutic levels, or fail to progress through the standard titration schedule