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Current Controversies Off-label/Cosmetic Use: There is considerable debate regarding the use of semaglutide for modest weight loss in non-diabetic individuals

Q: If a patient is losing weight steadily on a lower dose of semaglutide, should they increase per the recommended titration schedule or should they remain at the lower dose until it no longer becomes effective

Preclinical evaluation of the CDK4/6 inhibitor palbociclib in combination with a PI3K or MEK inhibitor in colorectal cancer

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Hamilton A, Zhang Q, Salehi A et al (2018) Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca(2+) mobilization from acidic stores in pancreatic alpha-cells