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PMCID: PMC5683004

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This decline may be due to the decreased GLP-1 secretion or impairment of L-cell development [15,16,17,18]

For example, MDR1 gene augments ferroptosis sensitivity by promoting GSH efflux, while cysteine dioxygenase 1 (CDO1) increases ferroptosis sensitivity by depleting cysteine and GSH (34, 35)

Allicin was proven to inhibit hypoxia-induced astrocyte apoptosis by increasing GPX1 expression, activating proto-oncogene tyrosine-protein kinase Src (Src)- protein kinase B (AKT)-extracellular signal-regulated kinase (ERK) phosphorylation, and decreasing lipid peroxidation