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However, their high cytotoxicity possibly compromising epithelial integrity greatly limited their clinical translation

Other mechanisms such as VPA-induced lipid peroxidation and glutathione depletion could also contribute to hepatotoxicity [59]

Instead, clinicians should acknowledge this risk and consider individualized risk-benefit strategies when prescribing GLP-1 RAs, particularly for patients with pre-existing ocular manifestations and must inform patients regarding possible ocular hazards while advocating for regular retinal examinations and assessments of visual acuity

A multidose version of Zepbound is under review by the FDA, Lilly said