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Anything that increases inflammation: There are more obvious things that increase inflammation like lack of sleep, a diet high in inflammatory foods, smoking, or underlying infections

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But gastrointestinal adverse events affected a significant portion of participants

In this regard, two recent case-control studies revealed association of maternal polymorphisms or haplotypes of the DNMT3B gene, coding for an enzyme required for the regulation of DNA methylation at centromeric and peri-centromeric regions of human chromosomes, with risk of having a birth with DS