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Transcriptional regulators of the enzymes include the peroxisome proliferator-activated receptors (PPARs) and a transcription factor coactivator PGC-1a (and involve the retinoid X receptor), but the details of the process are tissue dependent

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[PubMed: 11836274] 21

Other natural sources of Berberine include Hydrastis Canadensis (goldenseal), Berberis vulgaris (barberry), Berberis aquifolium (Oregon grape) and Berberis aristata (Indian Barberry)