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Efficacy and safety of glucagon-like-peptide-1 receptor agonists on body weight and cardiometabolic parameters in individuals with obesity and without diabetes: A systematic review and meta-analysis

This was not only a benefit to diabetic patients, but also to those looking to lose weight

4 A 2025 mechanistic study using RAMP1/RAMP3 knockout mice demonstrated this dependence directly: cagrilintide activated area postrema neurons and reduced body weight in wild-type animals but had essentially no effect in mice lacking these receptors, pinning its action to the AMY and AMY subtypes in the hindbrain

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