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This makes it a direct messenger from the mitochondria, signaling cellular energy status

This route achieves tissue concentrations 10-20 times higher than topicals, making it the preferred method for researchers seeking maximum effect

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions

B12 injections work by bypassing the digestive system entirely