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Arai J, Niikura R, Hayakawa Y, Kawahara T, Honda T, Hasatani K

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Common digestive effects include: Nausea (reported in approximately 15-20% of patients according to the SmPC) Vomiting Diarrhoea Constipation Abdominal discomfort or bloating These symptoms typically emerge during dose initiation or escalation and often improve over several weeks as the body adapts