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The glucagon pathway in particular produces effects, including thermogenesis and hepatic lipid mobilization, that no prior GLP-1 or GLP-1/GIP compound prepared the body for

This can potentially lead to an accumulation of semaglutide in the body, posing a risk of adverse effects

doi: 10.1002/osp4.84

By weeks 8 to 12 at therapeutic semaglutide doses, blood sugar control should approach your previous tirzepatide levels, though some patients on high-dose tirzepatide may not achieve identical HbA1c results with semaglutide alone

More recently, however, patients have started asking a different question: If 2.5 mg is still working, why should I increase? Its a fair questionand one that has generated thousands of conversations across online communities