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Thus, chemotherapeutic approaches to blocking DNA replication through disruption of disulfide reductase pathways will need to be cognizant of the potentially complete functional redundancy of the GSH and Trx pathways in animal systems, and sensitive to the various other physiological roles these pathways play in normal homeostatic and stress-response pathways

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BioMed Central ,

One of the ways that MTHFR gene mutation can make you susceptible to illness is by lowering your ability to make glutathione