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The cumulative effect of many missed doses will reduce overall efficacy

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In contrast, GLP-1 receptor agonists are particularly effective in reducing major adverse cardiovascular events, while their effect on HF hospitalization appears more modest, with relative risk reductions of approximately 11% (HR 0.89) in pooled analyses [6, 14]

Hypothalamic astrocytes express receptors for various peripheral hormones, including adipokines and insulin (99)

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