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Mendelian randomization A method using measured variation in genes (for example, single nucleotide polymorphisms) to examine the causal effect of an exposure on an outcome

Understanding why diagnosis takes so long requires examining the complex interplay between patient factors, provider knowledge, healthcare system structures, and the inherent challenges of the condition itself

Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner ( 2.3.2 Immune cell recruitment inhibition Apart from inflammatory cytokines secretion reduction, inhibited macrophage infiltration and immune cell recruitment also played a vital role in GLP-1RAs anti-inflammatory ability

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