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Other key agents in this class are dulaglutide and the novel dual GIP/GLP-1 receptor agonist, tirzepatide [16,17,18,19]

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Shortly after its success with diabetes treatment, Gotthardt and other scientists realized in the mid-2000s that insulinomas, typically a clump of many beta cells, also contain a high amount of GLP1Rs, making exendin-4 an attractive candidate to help localize these pesky tumors

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