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The mobile phases were MS solvent A (5% ACN, 0.1% FA) and B (90% ACN, 0.1% FA) at a flow rate of 0.2 ml/min with the gradient (the proportion of MS solvent B is given in %) represented in the Supplementary Table 6

These neurotrophic effects support neuronal survival, synaptic plasticity, and cognitive function maintenance during aging

Therefore, inhibitors combination against these antioxidant systems with such prooxidant properties is required to elevate the intracellular ROS concentrations within tumor cells and it may be crucial to devastate the antioxidant systems beyond the threshold of toxicity level

Razi Inst