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In summary, MIA mice consistently exhibited core behavioral features associated with Autism Spectrum Disorder (ASD), including impaired social interaction, reduced communication, and increased repetitive behaviors like grooming [1]

Consequently, Se deficiency can lead to inadequate chromatin condensation, which, in turn, affects sperm quality and causes reduced fertilization capacity (182)

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In addition, SIRT1, an NAD + -consumed enzyme, counteracts the effect of the circadian complex by deacetylating BMAL1 and the histones in the promoter region of other regulated genes

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