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Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus

They are not medicines and are not for human or veterinary use

Consistently, intestinal-specific overexpression of TXNIP abolished metformin-induced improvements in glucose tolerance, while pharmacological inhibition of GLUT1 similarly negated metformins glucose-lowering effects

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Finally, individual differences in baseline metabolic rate and prior exposure to dietary or behavioral weight loss strategies may influence the magnitude of BW reduction achieved with GLP-1 RAs, highlighting the complexity of therapeutic response in patients with T2DM [45]