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Due to the scope of this review and the current challenges in identifying individual pathophysiological factors in IBS patients, we propose a predominant symptom-based approach solely focused on pharmacological management (algorithm, Figure 4)

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Soybean L-a-Lecithin, fetal bovine serum (FBS), Phosphate buffered solution (PBS), MTT kit (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide), Ethanol (ACS reagent, 99.5%) and the other additional chemicals and solvents were obtained from Sigma Aldrich (St