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TABLE 2 Basic characteristics of included studies

Assess volume status

Repeated IM injections are painful and inconvenient, and other local side effects such as tissue irritation or fibrosis at injection sites are also concerns, leading to low long-term patient compliance ( 4.4 Intrathecal administration Intrathecal (IT) delivery involves administering the chelator directly into the CSF (often via lumbar puncture or an implanted reservoir), thereby bypassing the BBB ( Molecules administered by intrathecal administration still encounter barriers within the subarachnoid space for drug penetration from CSF into brain parenchyma, but IT dosing creates a favorable concentration gradient for drugs to diffuse

[DOI] [PubMed] [Google Scholar] 56.Henning SM, Niu YT, Lee NH, Thames GD, Minutti RR, Wang HJ, Go VLW, Heber D

In that case, if the combination is merely additive, the effect would be the following: In this equation, E is the %viability effect obtained from the CellTiter-Glo output