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(2) I (Intervention): GLP-1 RAs as a whole or as a single drug

The immediate activation of the adaptive ER stress response was reduced, but not blocked by GSTP1

In large RCTs, patients receiving semaglutide, 2.4 mg, lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28. (Source) It is important to note that GLP-1 is not a magic bullet for weight loss and should not be used as a substitute for a healthy lifestyle

GLP-1 agonists can be very effective at lowering blood sugar levels, but you may still need to take additional medications to reach your goals