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PMID: 25900608

If conclusively proven, this may help to explain the rapid rise is diabetes and metabolic disturbances, and offer the possibility of more specifically treating the underlying dysfunctions

These pleiotropic anti-inflammatory effects of DPP-4 inhibitors are incomparable to standard anti-inflammatory therapies (i.e., corticosteroids) and might be useful in the therapy of COVID-19 due to their other favorable effects, especially after the clinical findings, suggesting the lack of benefit from corticosteroids and even indicating to deleterious effects accompanied with late complications (Russel et al., 2020)

Subsequent studies showed a role for upregulation of the pro-inflammatory mediator NFB in the GPx1 / brain following MCAO-induced injury, and found that NFB contributes, in part, to the enhanced injury in the GPx1 / mice compared to wildtype mice [108]

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