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Genetic depletion of MAPKAPK2 abolishes these protective effects, whereas re-expression of MAPKAPK2 restores resistance to oxidative stressinduced cellular injury

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A still unsolved issue, connected with the role of carnitine in modulating gene expression (Figure 1) is the link between mitochondria and nucleus: acetylcarnitine produced in mitochondria would reach the nucleus providing acetyl units (Figure 2)

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