Also used in their study to visualize liposome permeation fluorescently was a 3D skin model, EpiDerm, featuring human dermal keratinocytes (Figure 8)
L.ChayC
Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor
(Published, July 2021) Pragya Sharma-Ghimire, Samuel Buchanan, Michael G
The upregulated gene clusters are enriched in extracellular matrix components (collagens I and III, decorin, elastin), antioxidant defense systems (superoxide dismutase, glutathione-related enzymes), DNA repair pathways, and anti-inflammatory mediators including IL-10 and TGF-beta family members