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Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice

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We thank Philipp Leippe and S Andreas Angermayr for critical reading and suggestions, and Julio Garcia and Stefania Scorzoni for their help with cell culture

Tirzepatide, also an incredibly effective weight loss peptide, is a dual agonist