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Late signs of deficiency can include anemia, neurological, and psychiatric symptoms

Taxifolin, a naturally occurring flavonoid found in plant-based foods like fruit, vegetables, wine, tea, and cocoa, attenuated lipopolysaccharide (LPS)-induced effects in Caco-2 cell monolayers by reducing secretion of the inflammatory markers, TNF-, IL-1, and IL-6 (Gong et al., 2022)

Studies have explored its effects on weight loss, NAFLD, 70 and neurodegenerative diseases such as AD

To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)

261 When combined with radiation or radiochemotherapy, KD slows tumor growth in lung cancer xenografts, potentially through a mechanism involving increased oxidative stress