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10.1371/journal.pgen.1006023 177 UlbrichtA.EpplerF

Third, there is evidence of successful restoration of aberrant mRNA splicing in non-NDD muscular conditions such as Spinal Muscular Atrophy (SMA) [89] and Duchenne Muscular Dystrophy (DMD) [90] through targeting splice junctions and cis-regulatory elements with ASOs [91, 92] (Fig

[12] [13] Suspected adverse reactions should be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

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Patients do best and experience fewer side effects if they gradually increase their doses of all diabetes and weight-loss drugs, Low Wang said