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Published Research Gene Expression Profiling Pickart et al

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21 In addition, there were also increased levels of proinflammatory cytokines, such as IL-1, TNF-, and IL-17, which correlated with an increased production of free radicals

Zinc, an anti-inflammatory antioxidant, which is required for the biological activity of thymulin, reduced the secretion of IL-1 beta (IC(50) = 62 microM), TNF-alpha (IC(50) = 1000 microM), and, to a lesser extent, IL-6