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Autoimmune disorders: In some cases, the bodys immune system can attack the cells that produce intrinsic factors, leading to pernicious anemia

Extended heat exposure can cause: Color darkening or brownish shifts Cloudiness from peptide aggregation Visible particle formation Loss of potency even without visible changes If your medication was shipped without adequate cold chain protection, or if it sat in a hot mailbox or delivery vehicle for hours, inspect it carefully before use