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The matrix physically blocks drug penetration, and bacteria inside biofilms alter their metabolic state in ways that make standard antibiotics far less effective

Bailey HH, Ripple G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C, Mahvi D, Schink J, Pomplun M, Mulcahy RT, Wilding G: Phase I study of continuous-infusion L-S, R-buthionine sulfoximine with intravenous melphalan

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If you dont consume sufficient vitamin B-12 then the majority of the cells in your body will suffer and fight to receive enough oxygen

Tkalcevic et al., 2007