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In brief, the frozen human atrial preparations were mechanically homogenized in a frozen SDS/bicarbonate solution to inhibit any enzymatic processes
doi: 10.1152/ajpendo.00036.2019 70 HanPBagennaBFuM
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When dissolved in water ( especially when dissolved in the polar solvent water!) we should likewise expect an acid-base reaction between the carboxylic acid and the amine
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