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P-01 Hereditary angioedema with normal C1-INH and PLG muta-tion treated with tranexamic acid: Beware of the risk of thrombosis Alexis Bocquet, David Launay, Isabelle Boccon-Gibod, Aurlie Du-Thanh, Delphiine Gobert, Sbastien Sanges, Laurence Bouillet Launay &Sanges University of Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000, INSERM, and the Department of Internal Medicine and Clinical Immunology, CHU Lille, National Reference Center for Angioedema (CREAK), Lille, France Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-01 Introduction: The anti-fibrinolytic, tranexamic acid (TA) can be proposed as a long term prophylaxis for hereditary angioedema (HAE), and seems to be specifically efficient for HAE with plasminogen gene mutation (HAE-PLG), a subset of HAE with normal C1-INH (HAE-nC1-INH)

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Some potential concerns with long-term use of synthetic drugs include: Digestive discomfort (nausea, bloating, diarrhea) Possible nutrient absorption issues over time The need for ongoing injections or high-cost prescriptions Unknown effects from long-term artificial hormone stimulation Natural herbs and whole-food extracts work differentlythey support the bodys own GLP-1 production and related digestive functions rather than replacing or overriding them