Changes in cellular markers and functions accompanying differentiation in HL60 promyelocytes by lymphocyte conditioned medium
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Signaling mediated by these receptors leads to the activation of Rac1, a GTPase of the RHO family, which regulates the polymerization and reorganization of the actin cytoskeleton in phagocytes, facilitating the formation of the phagocytic cup, the internalization of the apoptotic body and the formation of the phagosome - in a process mediated by the protein complexes LRP1-GULP and ELMO-DOCK, responsible for the activation of Rac1 [12, 13]
NAC provides cysteine, the rate-limiting substrate for intracellular glutathione synthesis, without relying on intact tripeptide absorption
Experiments were repeated three times independently, with similar results ( a-j )