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Although robust evidence is lacking for the primary prevention of cardiovascular disease using a combination of SGLT2is and GLP1-RAs, meta-analyses suggest potential benefits

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That number comes from McCoy et al

The STEP trials showed that while nausea peaked around week two, it typically improved markedly by week four

Combining Semaglutide with alcohol may result in dangerously low blood sugar levels, impaired efficacy of Semaglutide, and increased risk of medical conditions associated with the medication