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Depending on your injury, a trained professional will administer the injection weekly or bi-weekly until you experience significant pain relief

Maintaining cold chain for two separate compounds, carrying injection supplies, and managing daily versus weekly injection schedules while traveling requires planning

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Recently, a human gene mutation of PAPP-A2, a circulating and tissue protease with IGFBP-5 (and to some extent IGFBP-3) as its primary substrate (Gaudamauskes et al), was demonstrated to have a marked growth phenotype involving fetal and post-natal growth retardation in children in a consanguineous family (43)