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Additionally, the expression of mRNA and protein for both 25-hydroxylases (CYP2R1 and CYP27A1), 1--hydroxylase (CYP27B1), and VDR were downregulated, but that of 24-hydroxylase (CYP24A1) was significantly upregulated in the liver of HFD-fed mice compared to those in controls (Fig

The chondrocyte, architect of cartilage

However, the length of efficacy is unclear

PCSK5 plays a critical role in lipid metabolism 16 , cell proliferation, and migration 17 through the processing and conversion of various proteins 18

Annu Rev Immunol 2002