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Targeting development of incretin-producing cells increases insulin secretion

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It suppresses the production of gut-protective mediators like resolvin D5n-3 DPA (RvD5n-3 DPA) and the linoleic acid (LA) metabolic pathway, which normally function as aryl hydrocarbon receptor (AHR) ligands to promote Treg differentiation and suppress Th17 responses, thereby exacerbating inflammation (Flak et al., 2022

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10.1016/j.fsi.2012.10.013 66 WangJ.LiuZ.HeX.LianS.LiangJ.YuD.et al (2018b)