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DCHA and Boc-His (Trt)-OH are used as raw materials in the procedures, and accordingly His racemization risks can be reduced to the greatest extent

und Schritt 2: sukzessives Koppeln des in Schritt 1 hergestellten Gly-Harzes an eine Aminosure gem der Sequenz von Semaglutid durch sequentielle Kopplung

Addressing the loophole that allows manufacturers to set their own standards for making complex API requires Congress

In order to achieve the purpose, the technical scheme provided by the invention is as follows: (1) Preparation of compound 2: arg34GLP-1 (9-37) is taken as a starting material, side chain modification is carried out on 26-Lys of the Arg34GLP-1 (9-37) and the compound 1, acylation coupling reaction is carried out under certain reaction pH conditions, and solid is precipitated by adjusting isoelectric point of reaction liquid after post-treatment to obtain a compound 2

There are two other regulatory constructs relevant to this discussion