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The sequence is proline-rich, with three consecutive prolines followed by a fourth at position eight, and that conformationally constrained backbone is the usual structural explanation offered for the resistance

Additionally, IGF-1 improves insulin sensitivity, helping the body use nutrients more efficiently, which can support weight management and fat loss

Tips for Reducing Side Effects Common side effects include nausea, diarrhea, constipation, and abdominal discomfort, especially when starting or increasing doses

Giving your body time to adapt at each dose level significantly reduces gastrointestinal side effects