Common Side Effects Nausea (most common, peaks during dose escalation) Diarrhea, constipation, vomiting Decreased appetite, fatigue, headache Injection-site reactions (injectable forms) Rare: pancreatitis, gallbladder disease, kidney injury FDA boxed warning for medullary thyroid carcinoma (do not use with personal or family history of MTC or MEN2) How to Start GLP-1 Treatment See a clinician in-person primary care, endocrinology, obesity medicine, or US telehealth
Serum Calcitonin Calcitonin, a biological marker of MTC, was measured throughout the clinical development program [see Warnings and Precautions (5.1)]
Detoxification Support: It aids the liver in detoxifying harmful substances, which is crucial for maintaining a healthy body
For example, exendin and exenatide, two GLP-1 RAs, have been shown to suppress macrophage secretion of multiple pro-inflammatory cytokines, including IFN-, IL-17, IL-2, TNF-, IL-6, and IL-1 (103, 105)
Tirzepatide added GIP receptor activation and pushed results to 22.5%