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ChREBP was down-regulated in patients with NAFLD ( n = 22) compared to healthy controls ( n = 10), and instead, SREBP1c was reported to be one of the predominant regulators of DNL in NAFLD, upregulating genes coding for ACC1 and FAS [53]
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, et al
References: Novel Emerging Therapies for Erectile Dysfunction PMC
But absence of documented harm isnt the same as established safety, and for a medication that significantly suppresses appetite and affects metabolic signaling, caution is warranted
Because most of these peptides are sold as unregulated research chemicals, contamination and mislabeled potency add risk on top of the physiological effects
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