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Some oral GLP-1s, such as oral semaglutide, are fragile molecules called peptides that can be destroyed in your gut

Those details are important if irritation becomes a pattern

Advertisement While semaglutide works to mimic GLP-1 hormones, tirzepatide (like Mounjaro and Zepbound) is considered a dual agonist

endometriosis and uterine fibroids have also been reported with tamoxifen use

A 2025 study presented at the American Academy of Ophthalmology found that people using GLP-1 drugs were 68.6 times more likely to develop NAION and eight times more likely to develop diabetic retinopathy than those taking alternative diabetes medications