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Rheumatologist Dr

Adding further complexity, GLP-1RAs can stabilize the BBB (219, 220), raising the possibility that drugs with limited baseline uptake may improve their own CNS access over time, particularly in aging or NDD states where BBB dysfunction is common

What wasnt initially realized is that GLP-1 receptors are also found in brain regions governing motivation and reward, including the nucleus accumbens, the ventral tegmental area, the amygdala, the hippocampus, and other areas

SCFAs, including acetate, propionate, and butyrate, are major metabolites produced in the gut through the fermentation of dietary fiber by anaerobic bacteria

Popular GLP-1 medications like Semaglutide (Wegovy) and Tirzepatide (Mounjaro) have helped patients achieve significant weight loss when combined with lifestyle changes